Fulltext – Transdermal Drug Delivery System of Aceclofenac for Rheumatoid Arthritis An ideal transdermal patch should have flexibility, elasticity and softness. Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac. Rhee YS(1), Nguyen T, Park ES, Chi SC. transdermal matrix type patches to sustain its release characteristics. Key Words: Aceclofenac, Transdermal drug delivery, HPMC, Ethyl.

Author: Mezizahn Samulabar
Country: Qatar
Language: English (Spanish)
Genre: Video
Published (Last): 7 November 2011
Pages: 87
PDF File Size: 17.89 Mb
ePub File Size: 13.27 Mb
ISBN: 781-4-47082-956-8
Downloads: 38544
Price: Free* [*Free Regsitration Required]
Uploader: Tojaran

Propylene glycol Formulated transdermal patches were charachterised for their Correspondence to Author: These polymers were then dissolved in solvent spread in petri dish previously coated with a lubricant system containing water: Volume, IssueJuly Matrix type transdermal films loaded transdsrmal aceclofenac were prepared using solvent evaporation technique Table 1. The whole evaluated for aceclofenad physical appearance, uniformity, assembly was held like a beam balance and weights entrapment of any air bubble or precipitation of drug, were kept on the pan.

Formulated patches were attached with the centre of the patch. And d-limonene can have greater effect on increasing the drug flux and eliciting acecpofenac anti-inflammatory effect as compared to that of Span 20 for the transdermal delivery of aceclofenac.

Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac.

Rheumatoid Arthritis is associated with fatigue, chronic joint pains which may involve nociceptive as well as non-nociceptive components, including neuropathic components and prolonged stiffness after rest.

The transdermal films F2 and F3 prepared with d limonene showed greater percent drug release. After 6hrs petri dish was taken out of tray flexible. Patches were evaluated for their in-vitro drug release Department of Pharmacy, Patchea Kumar Goel profile and ex-vivo skin permeation studies. V Spectrophotometer in order to estimate amount shaved using depilatory cream and this skin was then of drug present in the sample. How to cite this article: Its non-invasive nature, ease of application and removal, So, the objective of present work is to develop a predetermined aecclofenac of drug aceclofeac, increased controlled release dosage form of Pregabalin other bioavailability of drug and decreased hepatic than oral route and injectables.


Solvent evaporation method generally provides products with good percentage of drug content. This was found to be in good agreement with previous studies Mamatha et al.

Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac.

United States Patent No. N Engl J Med.

International Journal of Pharmacology, It also finds its use in Transderaml drug delivery has certain advantages over peripheral diabetic neuropathy, fibromyalgia and post- other systems of drug administration which in turn therapeutic neuralgia. The percentage of moisture content was calculated as the difference between initial and final weight with respect to final weight.

Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use, Int. Hu Patchds, Zhu Y. But it is associated with short half-life h and gastro-intestinal side effects. Patches were also subjected to Institute of Technology, Ghaziabad, Uttar stability studies and skin irritation studies to determine their compatibility Pradesh, India with skin.

Email this article Login required.

RJPDFT – Formulation and Evaluation of Transdermal Patch of Aceclofenac

Receptor compartment was filled permeated through cellulose nitrate membrane; with Phosphate buffer pH 7. The film thickness was found to be in the range of 0. The transdermal films with permeation enhancers showed the greater anti inflammatory activity in carrageenan induced hind rat paw edema model.


Abstract Aceclofenac is a non steroidal anti inflammatory drug which is used to manage the chronic pain and inflammation in the patients of rheumatoid arthritis. In some previous studies d-limonene has been reported to be the very promising penetration enhancer Yang et al.

The ex vivo permeation study in the modified Franz diffusion apparatus through excised rat abdominal skin in pH 7. The solvent evaporation method was used in the preparation of the transdermal films. Increasing the concentration of enhancers showed the increased permeation of the drug. A 5 cm 2 area of dorsal portion of all the rats were shaved and cleaned with spirit.

International Journal of Pharmacology Volume 11 5: Marcel dekker, Inc, New York: For the patients of rheumatoid arthritis, delivering the drugs in transdermal films may not only increase the patient compliance but also provide the immediate and prolonged release of the drug.

Article Tools Print this article.

The transdermal films of aceclofenac can deliver the therapeutic concentration of the drug in a slow and prolonged manner so as to deliver the drugs for the whole day. Folding endurance was measured manually by folding the film repeatedly at a point till they broke.

In-vitro permeation studies of formulations were performed by using Franz diffusion cells. Solution was then filtered and drug specific time interval and equal amount of phosphate content was estimated spectrophotometrically at buffer was replaced each time to maintain volume of nm after suitable dilution.